Ethamsylate - instructions for use, indications, side effects, analogues and price

The hemostatic drug Etamsylate is used for the prevention and treatment of bleeding in surgery, gynecology, and other medical industries. It is prescribed for women with menstrual irregularities, to reduce heavy blood loss during menstruation. The purpose of the drug and the selection of its dosage form, regardless of the diagnosis and symptoms, should be performed by the attending physician.

Instructions for use Etamsylate

The hemostatic (hemostatic) agent Etamsilat is characterized by angioprotective, proaggregate actions. The drug stimulates an increase in the rate of development of platelets and their exit from the bone marrow. It is used to stop and prevent capillary and parenchymal bleeding, diapedetic hemorrhages, in surgery, gynecology, ophthalmic, dental, urological and otolaryngological practice during surgical interventions.

The hemostatic effect of Etamsylate is due to the formation of thromboplastin at the site of damage to the vessel and a decrease in the formation of prostacyclin in the vessel walls, which leads to a stop or decrease in bleeding. The antihyaluronidase activity of the main component prevents the destruction of mucopolysaccharides of the walls of capillaries, increases their resistance and reduces fragility. Taking the drug does not have a vasoconstrictor effect, does not contribute to thrombosis.

Composition and form of release

The drug Etamsylate is available in two dosage forms - tablets for oral administration and a solution for intramuscular or intravenous injection. Convex white tablets contain 250 mg of the main active ingredient (sodium ethamylate) and auxiliary components (sodium hydrogen phosphate dihydrate, sodium metabisulfite, povidone, potato starch, calcium stearate). Packed in blisters for 50 or 100 pieces.

Ethamzilate injection solution is a clear, colorless or slightly yellow colored liquid. Packed in ampoules of 2 ml, 1.2 or 10 ampoules per pack. The content of active and auxiliary components of the solution:


Content mg

Sodium Etamsylate


Sodium Disulfite


Disodium edetate


Purified water


Pharmacodynamics and pharmacokinetics

The active component of the drug - sodium ethamylate - promotes the formation of mucopolysaccharides and thromboplastin, providing hemostatic activity of the drug. Taking the medicine helps to normalize the rate of blood coagulation, increase the elasticity and stability of the capillary walls, reduce their permeability, and improve microcirculation processes. At the same time, the prothrombin time (blood coagulation time) does not change, normal platelet adhesion (gluing speed) is restored, and the hypercoagulation effect is not manifested.

With intravenous or intramuscular administration, the therapeutic effect begins after 10 minutes, the maximum effect occurs after 2 hours with a duration of action from 4 to 6 hours. With oral administration, the rate of onset of positive dynamics is lower, while the hemostatic parameters are better. Regardless of the method of application, about 72% of the dose taken is excreted in the bile, excreted in the urine during the day after administration.

Indications for use

The drug is used to treat or prevent capillary bleeding during surgical interventions or in case of emergency and diseases with concomitant symptoms (risk of bleeding). Indications for use are:

  • diabetic angiopathy;
  • hemorrhagic diabetic retinopathy;
  • hemorrhagic diathesis;
  • von Willebrand-Jurgens syndrome;
  • hemorrhagic vasculitis;
  • diapedesis;
  • hematuria;
  • polymenorrhea (menstruation with heavy blood loss, menstrual irregularities).
  • surgical interventions in otorhinolaryngology (tonsillectomy, microsurgical operations on the ear);
  • ophthalmic surgery (antiglaucomatous surgery, retinal surgery);
  • dental operations (removal of cysts, granulomas, tooth extraction);
  • urological operations;
  • gynecological practice (during operations on copiously supplied tissues)
  • with acute intestinal or pulmonary bleeding.

Dosage and administration

The duration of treatment with the use of Etamsilat, the scheme and form of administration, the volume of a single and daily dose are determined by the attending physician depending on the diagnosis and symptoms. The dosage recommended by the instructions for use is:

  • when taken orally: 250-500 mg 3-4 times a day (a single, single dose for oral administration is increased to 750 mg with appropriate indications);
  • intramuscularly or intravenously: 125-250 mg, 3-4 injections per day;
  • for parenteral administration: up to 375 mg;
  • in childhood: 10-15 mg / kg per day, 3 injections per day, in equal doses.

Ethamsylate Tablets

Oral administration of the drug is prescribed for the treatment and prevention of bleeding in diabetic microangiopathies and diathesis. Ethamzilate for heavy periods and for the treatment of cycle disorders is also recommended for oral administration. Possible treatment regimens:

  • Metro and menorrhagia during menstruation and treatment of dysfunctional uterine bleeding - 0.5 g once every 6 hours, the course of treatment - 5-12 days. Preventively - 1 tablet 4 times a day on bleeding days, and for the next two days of the cycle.
  • Diabetic angiopathy - 1-2 tablets 2-3 times a day, treatment duration 2-3 months.
  • Prevention of the risk of postoperative bleeding - 6-8 tablets per day with a uniform distribution of doses at each dose for 24 hours.

Etamsylate in ampoules

Ethamsilate injections are used to prevent bleeding before and after surgery with appropriate indications (2-4 ml intramuscularly or intravenously, an hour before surgery). If there is a risk of postoperative bleeding, 4-6 ml per day are prescribed. Possible application schemes:

  • hemorrhagic diathesis - 1.5 g, one injection per day, course duration 5-14 days;
  • in ophthalmology - 0.125 g (1 ml of solution) subconjunctival or retrobulbar;
  • in veterinary practice - 0.1 ml per kilogram of animal weight 2 times a day.

Etamzilate during pregnancy

During pregnancy, etamsylate is prescribed with caution. It is not recommended for use during the first trimester. If there is spotting or a threatened miscarriage at a later date, it is used in combination with Progesterone with constant monitoring of blood coagulation. The appointment should be made by the doctor leading the pregnancy, self-medication can lead to negative consequences for the health of the mother or fetus.

Drug interaction

It is unacceptable to mix Ethamsylate solution in the same syringe with other medications. With parallel therapy with the pharmaceutical group of dextrans, with the introduction of a drug with a dosage of 10 mg / kg one hour before their administration, a decrease in antiplatelet effect is possible; the introduction after does not have a pronounced hemostatic effect. Permissible combined use with aminocaproic acid, sodium menadione bisulfite.

Side effects and overdose

The course of treatment with the use of Ethamsilate in most cases is well tolerated, subject to the treatment regimen, daily dosage. No cases of overdose have been reported, with complicated bleeding caused by an overdose of anticoagulants, the use of specific antidotes is indicated. Possible side effects of taking the drug:

  • a feeling of discomfort or burning in the chest area;
  • heartburn;
  • stomach pains;
  • anemia;
  • decrease in intracranial pressure;
  • hyperemia of the skin of the face;
  • headache and dizziness;
  • arterial hypertension;
  • lowering systolic blood pressure;
  • paresthesia of the skin (numbness, tingling sensation) of the lower extremities.


The purpose of the drug Etamsylate is not indicated for diseases and conditions with concomitant increased thrombosis. Contraindications for taking instructions for use include:

  • thromboembolism;
  • thrombosis;
  • hemorrhage while taking anticoagulants;
  • increased blood coagulation;
  • acute porphyria;
  • bronchial asthma;
  • hemoblastosis in children;
  • hypersensitivity to the components of the drug.

Terms of sale and storage

Ethamsylate is dispensed in pharmacies as prescribed by the doctor. Keep the product out of the reach of children, in a dark place, at a temperature not exceeding 25 ° C. Shelf life - two years from the date indicated on the package.


The only registered complete structural analogue of the drug Ethamsilate is Dicinon. If side effects occur or if individual intolerance is detected, the replacement is performed by the attending physician with one of the following drugs:

  • Dicinone;
  • Vikasol;
  • Ezelin;
  • Methylergobrevin;
  • Tachocomb;
  • Impedil;
  • Gordox;
  • Tranexam;
  • Altodor.

Etamzilat Price

You can buy Etamsylat in a pharmacy or on specialized Internet resources, arranging home delivery. The average cost of all forms of release:

Release form

Price range, in rubles

Solution for intramuscular and intravenous administration, ampoules No. 10 2 ml 12.5%


Tablets number 50



Oksana, 28 years old. Ethamsilate at a monthly gynecologist recommended me to take after the second birth because of increased blood loss and violations of the duration of the cycle. I drank in tablets according to the prescribed scheme - 4 tablets every 6 hours during the first 8 days of the cycle. Everything normalized already in the second month of admission, the course went to the end. There were no side effects.
Anna, 42 years old. With uterine bleeding after a miscarriage, a course of Ethamsilate injection was prescribed - two injections per day for 7 days. Bleeding stopped after the first two injections. The product is inexpensive, acted quickly, there were no side effects, the general state of health during the course did not change. Pricked intravenously, tolerated the procedure well.
Marina, 33 years old. During pregnancy, she was preserved at 18 weeks due to strong spotting. Ethamzilate was injected intravenously for two days (ampoule twice a day), then another 5 days intramuscularly one ampoule per day. Observed bed rest, bleeding stopped after 3 days. Further, the pregnancy proceeded without incident, the child is healthy.
Attention! The information presented in the article is for guidance only. Materials of the article do not call for independent treatment. Only a qualified doctor can make a diagnosis and give recommendations for treatment based on the individual characteristics of a particular patient.

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