Over-the-counter antidepressants: a list of the best drugs

Every second resident of the metropolis suffers from depression. To treat this ailment, psychiatrists or neurologists prescribe special medicines. Many patients are wondering if strong antidepressants can be bought without prescription. It is important to note that for the purchase of a powerful tool, an appointment is necessary, because they have a lot of contraindications. There are light medications that can help cope with the symptoms of a nervous breakdown and are sold over the counter.

Indications for the use of antidepressants

Before buying over-the-counter depression tablets in a pharmacy, it is important to make sure that the problem requires medical treatment. Perhaps a person only needs to eliminate the factors that provoke the development of the symptoms of the disease. Experts recommend that before starting taking pills, revise your lifestyle, avoid stress, relax more. Over-the-counter medicines are not suitable for people with severe depressive disorders. This category of patients definitely needs specialist advice and proper treatment.

All antidepressants have side effects, contraindications, therefore, before using them, it is important to consult a neurologist or psychiatrist. The drugs have different chemical composition, structure, differ in the ways they affect the body. The same medicine can affect different patients in different ways, therefore it is not worth treating depression with medication alone. This is especially true for chronic forms of mental illness.

If you need to reduce the susceptibility of the nervous system to external stimuli, then you can use light antidepressants without prescription. Such drugs significantly improve the quality of human life without causing serious harm to health. You can use them in the following pathological conditions:

  • pain of uncertain nature;
  • anorexia;
  • sleep disturbance, appetite;
  • bulimia
  • groundless anxiety;
  • attention disorder;
  • chronic fatigue;
  • alcohol dependence;
  • irritability;
  • drug addict.

Herbal Over-the-Counter Antidepressants

Herbs are considered the safest drugs for depression based on medicinal herbs. They will help with stress, nerve exhaustion, various phobias, appetite and sleep disorders. Herbal medicines for depression without prescriptions do not have a negative effect, gently affect the body. Before taking any tablets or capsules, you should carefully read the composition, indications, side symptoms and instructions for use.


This tool is one of the most popular antidepressants based on natural ingredients. The composition of the herbal preparation includes extracts of the following herbs:

  • hop;
  • St. John's wort
  • hawthorn;
  • Melissa;
  • valerian.

This mild antidepressant is especially popular among office workers, for whom the state of permanent stress and continuous time pressure has become familiar. Novo-Passit helps to cope with menopause, neurocirculatory dystonia, irritability, migraine, increased nervousness, neurasthenia, normalizes sleep. The drug provides a stable sedative effect. You can buy the medicine in the form of tablets or syrup. The price varies from 200 to 600 rubles.

Before using the drug without a doctor’s prescription, it is worth examining the contraindications. These include the following:

  • myasthenia gravis;
  • age up to 12 years;
  • allergy to components:
  • liver disease
  • epilepsy;
  • head injuries;
  • acute diseases of the digestive tract;
  • alcoholism;
  • brain diseases.

If you do not adhere to the instructions, taking Novo-Passit can cause problems with concentration, drowsiness, nausea, cramping. Tablets take 1 pc. three times daily with an interval of 4-6 hours. A double dosage is allowed if the patient is in a serious condition. With the development of side symptoms, they drink ½ tablets in 1 dose. Syrup is taken three times a day for 5-10 ml. If the patient does not tolerate the antidepressant, then a single dose is reduced to 2.5 mg.


Another popular drug based on natural ingredients that you can buy without a prescription from a doctor. Especially for patients with intermittent sleep, insomnia, early awakenings, there is a separate form of the drug - Persian nocturnal. The standard version of the drug is mild. The antidepressant is available in the form of tablets, contains extract of lemon balm, peppermint, valerian. The medicine provides a pronounced antispasmodic, sedative effect, fights with increased excitability. The cost of tablets is 195-250 rubles.

Persen is effective in various types of disorders of the nervous system. Indications for use of tablets are as follows:

  • neuroses in which potent therapy is not necessary;
  • vegetovascular dystonia;
  • insomnia;
  • prevention of psychosomatic manifestations in individuals subject to stress.

Against the background of taking the tablets, patients may develop constipation, allergic reactions, bronchospasm, peripheral edema. Before using Persen, it is worth familiarizing yourself with the contraindications. These include the following:

  • fructose or lactose intolerance;
  • cholangitis;
  • glucose galactose malabsorption;
  • cholelithiasis;
  • age up to 12 years;
  • arterial hypotension;
  • hypersensitivity to the components;
  • lactation period;
  • pregnancy;
  • gastroesophageal reflux disease.

Persen provides for the use of the drug orally, regardless of food intake. Tablets must be washed down with water. Adults and adolescents over 12 years of age show their use 2-3 times a day for 1 pc. With insomnia, take 2-3 tablets 30-60 minutes before bedtime. You can not drink more than 12 pcs. per day to avoid overdose of the drug. The course of therapy should not exceed 1.5 months. In case of an overdose, the patient may develop weakness, lethargy, tremor of the extremities, nausea, dizziness. Persian intoxication has not been previously recorded.


This natural remedy with a minimum number of contraindications helps to improve mood, increase efficiency. Neuroplant is dispensed without a prescription from a doctor. The drug contains ascorbic acid, St. John's wort extract. Admission Neuroplant helps to improve the patient's psycho-emotional state and mood, provides an antidepressant effect. Drinking pills is recommended for depression, pain of unknown origin, anxiety, psycho-vegetative disorders. Price - from 340 rubles.

Before you start taking Neuroplant, it is important to familiarize yourself with the contraindications. These include the following:

  • taking HIV protease inhibitors (cyclosporin or indinavir);
  • increased photosensitivity;
  • under 12 years old.

Tablets take 1 pc. 2-3 times a day, depending on the condition of the patient. The course of therapy is in no way limited in time due to the comparative safety of the drug. The following side symptoms are possible while taking a Neuroplant:

  • photosensitivity;
  • itchy skin;
  • dyspeptic disorders;
  • increased fatigue of the body;
  • psycho-emotional stress.

Lewsee extract

Considering cheap antidepressants without prescriptions by doctors, it is worth noting this remedy. Leuzea extract has a general tonic, adaptogenic, stimulating, firming effect on the body, improves mood, improves performance. A medicine is produced in the form of tincture and dragees. An antidepressant is produced using a dry extract of safflower-like rhizome rhizomes. The cost of the drug is from 90 rubles.

Before taking tinctures or tablets, it is worth familiarizing yourself with the indications. Leuzea extract is effective in the following conditions:

  • asthenia;
  • overwork (intellectual or physical);
  • decreased performance;
  • premenstrual syndrome;
  • vegetovascular disorders;
  • period of convalescence (recovery of the body after serious illness).

Although the drug has a natural composition and is dispensed from pharmacies without a prescription from a doctor, it has an exciting effect on the nervous system and has a large number of contraindications. These include the following:

  • pregnancy;
  • lactation period;
  • chronic pathology of the liver or kidneys;
  • arterial hypertension;
  • trouble sleeping;
  • arrhythmia;
  • acute infectious diseases;
  • increased nervousness;
  • epilepsy;
  • alcoholism;
  • hypersensitivity to the components;
  • under 12 years old.

It is important to note that the maral root contained in this antidepressant often provokes the development of side symptoms. Against the background of taking Leuzea extract, the following side effects can be observed:

  • increased blood pressure (blood pressure);
  • dyspeptic disorders;
  • insomnia;
  • headache;
  • increased irritability.

Instructions for use of the drug depend on the chosen form:

  • Liquid extract for alcohol is taken 20-30 drops 2-3 times every day. You can dilute the medicine with water. The course of therapy is no more than 1-1.5 months.
  • Tablets or dragees are taken with food for 2-3 pieces up to 2 times daily. The course of treatment is no longer than 1 month.
  • Drink homemade tincture 100 ml before meals in the morning and at lunch. For its preparation, 1 gram of boiled water is brewed with 1 gram of dry roots, boiled in a water bath for 15 minutes, cooled. The course of therapy is 2-3 weeks.

Over-the-counter synthetic antidepressants

In addition to natural preparations, in the pharmacy you can buy synthetic tranquilizers without prescriptions from a doctor. They also gently affect the patient's body, but contain active chemicals. Mild tranquilizers can be used to correct minor nervous disorders. Before using antidepressants, it is worth studying the instructions for use, contraindications and composition of the drug.


Among the inexpensive and effective over-the-counter antidepressants, these pills are the best known. Glycine is especially popular among students and schoolchildren during the exams. The price of packaging is 17-40 rubles. The tool is made on the basis of an interchangeable amino acid that activates metabolic processes in the body. Glycine helps to cope with aggressiveness, increased nervousness, psycho-emotional stress. The drug activates brain activity, reduces the severity of autonomic disorders.

An antidepressant has practically no contraindications, except for hypersensitivity to the components. During pregnancy and lactation, women can take Glycine only after consulting a doctor. Of the side symptoms in the annotation, only allergic reactions are indicated. The dosage and method of using the tablets are selected individually. For sleep disorders, drink 1 tablet at night. To improve performance, with lesions of the central nervous system (central nervous system) and psychoemotional stress, drink 1 pc. 2-3 times daily. The course of therapy is 2-4 weeks.


This antidepressant is characterized by low toxicity, mild action. Afobozole is dispensed from pharmacies without a prescription. It is a selective non-benzodiazepine tranquilizer (anxiolytic). The antidepressant does not affect benzodiazepine receptors, it affects the sigma-1 receptors in the brain. Taking the drug helps to improve memory, control emotions, fine motor skills, sensory perception. The medicine shows effectiveness in a variety of pathological conditions. Afobazole is available in tablets. Packing price: 375-450 rubles.

Before you start taking an antidepressant, you should read the indications. Afobazole is effective in the following disorders:

  • anxiety conditions;
  • asthenic neurosis;
  • premenstrual syndrome in women;
  • VVD (vegetovascular dystonia);
  • NDC (neurocircular dystonia);
  • sleep disturbances;
  • withdrawal syndrome in the treatment of tobacco dependence;
  • neurasthenia;
  • alcohol withdrawal (alcohol withdrawal syndrome).

The drug is relatively safe and dispensed from pharmacies without a prescription, but has many contraindications. These include:

  • allergy to components;
  • age up to 18 years;
  • galactosemia (galactose intolerance);
  • pregnancy;
  • the period of breastfeeding;
  • intolerance to monosaccharides;
  • lactase deficiency.

Patients may develop side effects while taking an antidepressant. Often Afobazole provokes the following conditions:

  • itching of the skin;
  • urticaria;
  • tonsillitis;
  • rhinitis;
  • headaches;
  • sneezing
  • nausea
  • vomiting
  • dermatitis.

According to the instructions, an antidepressant is taken after meals. A single dose of the drug is 10 mg, daily - 30 mg. Drink Afobazole 1 tablet up to 3 times daily. The course of therapy is 2-4 weeks. The effect of an antidepressant is noted after 20 days of use. Individually, the daily dosage and duration of taking the tablets may increase. Afobazole treatment is recommended to coordinate with a specialist.


This drug is part of the group of nootropics. Tenoten is a homeopathic remedy in the form of lozenges with a pronounced antidepressant effect. The drug contains affinity-purified antibodies to the brain-specific protein S-100. Tenoten has an anti-anxiety, neuroprotective, calming and anti-hypoxic effect. Pills help to cope with psychoemotional overloads, support the body in cases of cerebrovascular accident and intoxication.

Indications for the use of an antidepressant are nervous disorders, increased irritability, autonomic disorders. Tenoten is dispensed from pharmacies without a prescription, practically has no contraindications and side effects. It is possible to use this tool for the treatment of nervous disorders in children, nursing mothers and pregnant women. The cost of the drug is from 200 rubles per package.

The drug is taken orally, regardless of the period of food intake. The tenoten treatment regimen for depression is as follows:

  • 1-2 tablets at a time;
  • no more than 4 receptions per day;
  • the course of therapy is calculated individually from 1 to 3 months.


Another good over-the-counter antidepressant is this remedy, which is part of the group of nootropics. Phenotropil helps to improve mood, increase the body's resistance, regulate the processes of inhibition and excitation in the cerebral cortex, activate mental activity, and increase tissue resistance to hypoxia. Contraindications (except hypersensitivity to the components) Phenotropil has not. The cost of this tool starts from 500 rubles per package.

The medicine should be taken for disorders of the nervous system. Indications are depressive disorders, which are accompanied by the following symptoms:

  • apathy;
  • trouble sleeping;
  • lethargy;
  • violation of metabolic processes;
  • problems with cerebral circulation.

Phenotropil is taken orally, washed down with a large volume of clean water. It is recommended to drink the medicine in the morning. The maximum daily dose of antidepressant is 750 mg. At one time, an adult patient can take 100-300 mg. The course of treatment of depressive conditions is up to three months. In some cases, you can extend the time of use of capsules by 30 days. In order to increase efficiency Phenotropil is taken in 100-200 ml in the morning.The course of therapy in this case is 15 days.


Another remedy for depression that can be bought without a prescription from a doctor is widely used for neurotic and mental disorders. Neurofulol contains the following substances:

  • amino acids (methionine and tryptophan);
  • magnesium;
  • B vitamins

Antidepressant helps maintain the functioning of the nervous system. Indications for the use of the drug are as follows:

  • chronic fatigue;
  • panic attacks;
  • phobias;
  • neurotic disorders;
  • depressive states;
  • digestive disorders caused by stress;
  • anxiety conditions;
  • trouble sleeping.

Reception of Neurofulol helps to increase efficiency, improve mental endurance of the body, the general well-being of the patient and normalize the central nervous system. The drug has almost no contraindications, except for hypersensitivity to the components. Side effects during therapy with this antidepressant are not noted, therefore, it is sold without a prescription. The price of the drug starts from 800 rubles per package.

Neurofulol is recommended to drink 1 pill 3 times a day after meals. The interval between doses should not exceed 8 hours. The course of therapy is 3 weeks. Depending on the specific case, the dosage and duration of treatment can be adjusted by a specialist. If there is no effect or the development of side symptoms, you should consult a doctor for advice.

Attention! The information presented in the article is for guidance only. Materials of the article do not call for independent treatment. Only a qualified doctor can make a diagnosis and give recommendations for treatment based on the individual characteristics of a particular patient.

Watch the video: How to Find the Right Antidepressant Anxiety Medication (February 2020).